Imidazoline Receptors
نویسندگان
چکیده
منابع مشابه
Tizanidine may discriminate between imidazoline-receptors and alpha 2-adrenoceptors.
The selectivity of tizanidine to the imidazoline-receptor and alpha 2-adrenoceptor recognized by 3H-p-aminoclonidine was examined in rat kidney membranes and was compared with those of other imidazoline compounds. Tizanidine bound to the imidazoline-receptors with approximately 20 times higher affinity than the alpha 2-adrenoceptors. The order of relative selectivity to imidazoline receptor was...
متن کاملImidazoline receptors in relaxation of acetylcholine-constricted isolated rat jejunum.
Since 20 years the concept of specific imidazoline receptors has remained controversial. The problem with imidazoline receptors is mostly due to their functional similarity to alpha-adrenoceptors. In this work, a pharmacodynamic model of isolated rat jejunum longitudinal muscle strips constricted with acetylcholine (Ach) was applied to separate functional properties of the two types of receptor...
متن کاملPresynaptic I1-imidazoline receptors reduce GABAergic synaptic transmission in striatal medium spiny neurons.
Imidazoline receptors are expressed widely in the CNS. In the present study, whole-cell patch-clamp recordings were made from medium spiny neurons in dorsal striatum slices from the rat brain, and the roles of I1-imidazoline receptors in the modulation of synaptic transmission were studied. Moxonidine, an I1-imidazoline receptor agonist, decreased the GABAA receptor-mediated IPSCs in a concentr...
متن کاملImidazoleacetic acid-ribotide induces depression of synaptic responses in hippocampus through activation of imidazoline receptors.
Imidazole-4-acetic acid-ribotide (IAA-RP), an endogenous agonist at imidazoline receptors (I-Rs), is a putative neurotransmitter/regulator in mammalian brain. We studied the effects of IAA-RP on excitatory transmission by performing extracellular and whole cell recordings at Schaffer collateral-CA1 synapses in rat hippocampal slices. Bath-applied IAA-RP induced a concentration-dependent depress...
متن کاملAllantoin activates imidazoline I-3 receptors to enhance insulin secretion in pancreatic �-cells
Background: Imidazoline I3 receptors (I-3R) can regulate insulin secretion in pancreatic β-cells. It has been indicated that allantoin ameliorates hyperglycemia by activating imidazoline I2 receptors (I-2R). Thus, the effect of allantoin on I-3R is identified in the present study. Methods: We used male Wistar rats to screen allantoin’s ability for lowering of blood glucose and stimulation of in...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1992
ISSN: 1941-7225,0895-7061
DOI: 10.1093/ajh/5.4.47s